About Ketoconazole Interactions of Other Drugs

Ketoconazole is a type of drug used to treat fungal infections of the skin. For example, ringworm in the legs, body, or groin, panu, seborrheic dermatitis, and dandruff. This anti-fungal drug can kill the fungus that causes infection, while preventing it.

Brand:
Formyco, Formico Cream, Nizol, Nizoral Cream, Nizoral-SS, Solinfec, Solinfec Cream, Okasid, Tokacid Cream, Zoloral Cream, Zoloral-SS.

About Ketoconazole

• Anti-fungal Medication Group
• Free drug categories and recipes
• Benefits, Handles yeast infections, treat dandruff
• Used by Adults and children over 2 years old
• Shape Tablets, topical medicines, shampoo
• Category of pregnancy and lactation Category C: Animal experiments have shown fetal side effects, but no controlled studies have been conducted in pregnant women. Drugs should only be used if the expected benefits exceed the magnitude of the risk to the fetus.

WARNING:

1. For women who are planning pregnancy and are pregnant, consult a physician first before using ketoconazole.
2. While breastfeeding mothers are prohibited from using this drug.
3. It is important for the patient to use this medicine within the time period recommended by the physician to ensure that the fungal cause of the infection is completely destroyed, and prevent it from growing again.
4. Ketoconazole topical should only be used as an external medicine. do not use them on wounded, scratched, or burned skin.
5. Please be alert if you have irregular heartbeat (arrhythmia), allergy to other antifungal drugs, liver disorders, low levels of tertosterone, adrenal gland disorders, and low stomach acid.
6. Avoid alcohol consumption during oral ketoconazole use as it may increase the risk of liver disorders.
7. During using ketoconazole, tell your doctor before undergoing any medical treatment.
8. If an allergic reaction or an overdose occurs, see your doctor immediately.

Dose:

The dose of ketoconazole depends on the type of infection, the degree of difficulty, and the given form of the drug.

The recommended cream and ketoconazole shampoo is 2%. Cream ketoconazole can be smeared 1-2 times a day on the infected part and ketoconazole shampoo can be used as much as 1 time a day for a maximum of 5 days.

While ketoconazole in tablet form, taken with a dose of 200 mg per day. This dose can be increased by a doctor up to 400 mg if needed. Especially for children, the oral ketoconazole dose will be adjusted to the patient's weight.

How to properly use Ketoconazole

Use ketoconazole as recommended by your doctor and do not forget to read the description on the package. discipline to use this drug before the period specified by the doctor. Although the infection appears to have healed, the fungus still has the potential to grow back.

Before applying ketoconazole cream, clean and dry the infected part first. Do not forget to wash your hands after applying this medicine to avoid spreading the infection to other parts of the body or to others.

For a ketoconazole shampoo, flatten the shampoo shampoo to cover all the hair and scalp. After that, let stand for 5 minutes before rinsed clean. If on the eyes, immediately flush with water.

Make sure there is sufficient time between one dose with the next dose during taking oral ketocoazole. Try to drink it at the same hour each day in order to maximize the effects of the drug.

For patients who forget to take oral ketocoazole, it is advisable to do so immediately if the break with the next consumption schedule is not too close. When it is near, ignore and do not double the dose.

Interactions of Ketoconazole and Other Drugs
There are various drugs that have the potential to cause undesirable reactions if taken in conjunction with ketoconazole. Some of them include:

• Muscarinic receptor antagonist (MRA), magnesium hydroxide antacids, H2 inhibitors, proton-pump inhibitors (PPIs) and sucralfates; decrease the body's absorption capacity against ketoconazole.
• Rifampicin, isoniazid, efavirenz, nevirapine, and phenytoin; lower levels of ketoconazole in the blood.
• Family planning pills; its effectiveness may decrease due to ketoconazole.
• Digoxin, oral anticoagulant, sildenafil, and tacrolimus; the effect of increasing enzyme levels to speed up drug expenditure from the body.
• Midazolam and triazolam; sedative and hypnotic effects of these drugs can be increased by co-administration with ketoconazole.
• Astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine; levels of these drugs in the blood can increase due to ketoconazole, also potentially leading to heart rhythm disturbances.
• Lovastatin and simvastatin; increased risk of muscle disorders.
• Nisoldipine; the levels of these drugs can increase significantly in the blood due to ketoconazole.
• Eplerenone; increased risk of hyperkalemia and hypotension.
• Ergotamine and dihydroergotamine; enhancement

Recognize Side Effects and Dangers of Ketoconazole
Each drug has the potential to cause side effects, as well as ketoconazole. Some of the side effects that may occur when using this antifungal include:

1. Nausea.
2. Diarrhea.
3. Headache.
4. Stomach ache.
5. Biduran.
6. Thrombocytopenia.
7. Fever.
8. Shivering.
9. Rash or skin irritation.
10. Sensitive to light.
11. Burning sensation or sore on the skin.

Immediately stop taking medication and see a doctor if you have an allergic reaction or serious side effects, such as flatulence, swelling of the hands, feet or ankles, numbness, chest pain, visual impairment, dark urine, weakness, fatigue, irregular heartbeat, and the desire to commit suicide.

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