*Incest*is included in inbreeding. Genotype frequency for such case can be calculated by using

## Formula of Hardy-Weinberg Law

## The F Value in variety of incest are as follows

For example, in a random marriage in society, the probability of PKU case to occur is about I out of 10,000. In accordance to

**Hardy-Weinberg Law**, the genotype frequency is:

If

**incest**between level 1 nephews occur, then the probability of PKU case to occur is

Based on the above examples, we can conclude that the chance of PKU To appear in the marriage between level I cousins is 2.2 times bigger than That in a random or a non incest marriage.

## lncest Can Cause Genetic Disease

The research result indicates that there is a tight correlation between incest occuring in a society and the number of genetic disease case. The more incest occurs in society, the bigger the chance of genetic disease to appear. more Hardy–Weinberg principleSource:

*formula Hardy-Weinbreg disease*

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